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Prediction of LDL cholesterol response to statin using transcriptomic and genetic variation

Overview of attention for article published in Genome Biology, September 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
twitter
25 X users
facebook
1 Facebook page
googleplus
1 Google+ user

Readers on

mendeley
67 Mendeley
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Title
Prediction of LDL cholesterol response to statin using transcriptomic and genetic variation
Published in
Genome Biology, September 2014
DOI 10.1186/s13059-014-0460-9
Pubmed ID
Authors

Kyungpil Kim, Eugene Bolotin, Elizabeth Theusch, Haiyan Huang, Marisa W Medina, Ronald M Krauss

Abstract

Statins are widely prescribed for lowering LDL-cholesterol (LDLC) levels and risk of cardiovascular disease. There is, however, substantial inter-individual variation in the magnitude of statin-induced LDLC reduction. To date, analysis of individual DNA sequence variants has explained only a small proportion of this variability. The present study was aimed at assessing whether transcriptomic analyses could be used to identify additional genetic contributions to inter-individual differences in statin efficacy.

X Demographics

X Demographics

The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
United States 1 1%
Unknown 65 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 21%
Student > Ph. D. Student 13 19%
Student > Master 9 13%
Student > Bachelor 6 9%
Other 5 7%
Other 14 21%
Unknown 6 9%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 16 24%
Medicine and Dentistry 12 18%
Agricultural and Biological Sciences 12 18%
Computer Science 7 10%
Pharmacology, Toxicology and Pharmaceutical Science 4 6%
Other 9 13%
Unknown 7 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 35. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2022.
All research outputs
#1,132,957
of 25,373,627 outputs
Outputs from Genome Biology
#838
of 4,467 outputs
Outputs of similar age
#12,100
of 264,647 outputs
Outputs of similar age from Genome Biology
#10
of 105 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,647 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 105 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.