Title |
Dual roles for ubiquitination in the processing of sperm organelles after fertilization
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Published in |
BMC Developmental Biology, February 2014
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DOI | 10.1186/1471-213x-14-6 |
Pubmed ID | |
Authors |
Connie Hajjar, Katherine M Sampuda, Lynn Boyd |
Abstract |
The process of fertilization involves a cell fusion event between the sperm and oocyte. Although sperm contain mitochondria when they fuse with the oocyte, paternal mitochondrial genomes do not persist in offspring and, thus, mitochondrial inheritance is maternal in most animals. Recent evidence suggests that paternal mitochondria may be eliminated via autophagy after fertilization. In C. elegans, sperm-specific organelles called membraneous organelles (MO) cluster together with paternal mitochondria immediately after fertilization. These MOs but not the mitochondria become polyubiquitinated and associated with proteasomes. The current model for the elimination of paternal mitochondria in C. elegans is that ubiquitination of the MOs induces the formation of autophagosomes which also capture the mitochondria and cause their degradation. |
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