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Targeted germ line disruptions reveal general and species-specific roles for paralog group 1 hox genes in zebrafish

Overview of attention for article published in BMC Developmental Biology, June 2014
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Mentioned by

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2 tweeters

Citations

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8 Dimensions

Readers on

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29 Mendeley

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Title
Targeted germ line disruptions reveal general and species-specific roles for paralog group 1 hox genes in zebrafish
Published in
BMC Developmental Biology, June 2014
DOI 10.1186/1471-213x-14-25
Pubmed ID
24902847
Authors

Steven E Weicksel, Ankit Gupta, Denise A Zannino, Scot A Wolfe, Charles G Sagerström

Abstract

The developing vertebrate hindbrain is transiently segmented into rhombomeres by a process requiring Hox activity. Hox genes control specification of rhombomere fates, as well as the stereotypic differentiation of rhombomere-specific neuronal populations. Accordingly, germ line disruption of the paralog group 1 (PG1) Hox genes Hoxa1 and Hoxb1 causes defects in hindbrain segmentation and neuron formation in mice. However, antisense-mediated interference with zebrafish hoxb1a and hoxb1b (analogous to murine Hoxb1 and Hoxa1, respectively) produces phenotypes that are qualitatively and quantitatively distinct from those observed in the mouse. This suggests that PG1 Hox genes may have species-specific functions, or that anti-sense mediated interference may not completely inactivate Hox function in zebrafish.

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Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 14%
Researcher 4 14%
Student > Master 4 14%
Professor > Associate Professor 3 10%
Student > Bachelor 2 7%
Other 5 17%
Unknown 7 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 55%
Biochemistry, Genetics and Molecular Biology 2 7%
Chemical Engineering 1 3%
Medicine and Dentistry 1 3%
Unknown 9 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 April 2015.
All research outputs
#9,508,019
of 12,372,276 outputs
Outputs from BMC Developmental Biology
#225
of 289 outputs
Outputs of similar age
#132,833
of 215,261 outputs
Outputs of similar age from BMC Developmental Biology
#2
of 2 outputs
Altmetric has tracked 12,372,276 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 289 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 215,261 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.

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