Title |
Targeted germ line disruptions reveal general and species-specific roles for paralog group 1 hox genes in zebrafish
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Published in |
BMC Developmental Biology, June 2014
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DOI | 10.1186/1471-213x-14-25 |
Pubmed ID | |
Authors |
Steven E Weicksel, Ankit Gupta, Denise A Zannino, Scot A Wolfe, Charles G Sagerström |
Abstract |
The developing vertebrate hindbrain is transiently segmented into rhombomeres by a process requiring Hox activity. Hox genes control specification of rhombomere fates, as well as the stereotypic differentiation of rhombomere-specific neuronal populations. Accordingly, germ line disruption of the paralog group 1 (PG1) Hox genes Hoxa1 and Hoxb1 causes defects in hindbrain segmentation and neuron formation in mice. However, antisense-mediated interference with zebrafish hoxb1a and hoxb1b (analogous to murine Hoxb1 and Hoxa1, respectively) produces phenotypes that are qualitatively and quantitatively distinct from those observed in the mouse. This suggests that PG1 Hox genes may have species-specific functions, or that anti-sense mediated interference may not completely inactivate Hox function in zebrafish. |
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Geographical breakdown
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France | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 13% |
Researcher | 4 | 13% |
Professor > Associate Professor | 4 | 13% |
Student > Master | 4 | 13% |
Student > Bachelor | 2 | 6% |
Other | 5 | 16% |
Unknown | 8 | 26% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 16 | 52% |
Biochemistry, Genetics and Molecular Biology | 3 | 10% |
Chemical Engineering | 1 | 3% |
Medicine and Dentistry | 1 | 3% |
Unknown | 10 | 32% |