Title |
The basal epithelial marker P-cadherin associates with breast cancer cell populations harboring a glycolytic and acid-resistant phenotype
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Published in |
BMC Cancer, October 2014
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DOI | 10.1186/1471-2407-14-734 |
Pubmed ID | |
Authors |
Bárbara Sousa, Ana Sofia Ribeiro, Ana Rita Nobre, Nair Lopes, Diana Martins, Céline Pinheiro, André Filipe Vieira, André Albergaria, René Gerhard, Fernando Schmitt, Fátima Baltazar, Joana Paredes |
Abstract |
Cancer stem cells are hypoxia-resistant and present a preponderant glycolytic metabolism. These characteristics are also found in basal-like breast carcinomas (BLBC), which show increased expression of cancer stem cell markers.Recently, we demonstrated that P-cadherin, a biomarker of BLBC and a poor prognostic factor in this disease, mediates stem-like properties and resistance to radiation therapy. Thus, the aim of the present study was to evaluate if P-cadherin expression was associated to breast cancer cell populations with an adapted phenotype to hypoxia. |
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