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An improved Bacillus subtilis cell factory for producing scyllo-inositol, a promising therapeutic agent for Alzheimer’s disease

Overview of attention for article published in Microbial Cell Factories, December 2013
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Title
An improved Bacillus subtilis cell factory for producing scyllo-inositol, a promising therapeutic agent for Alzheimer’s disease
Published in
Microbial Cell Factories, December 2013
DOI 10.1186/1475-2859-12-124
Pubmed ID
Authors

Kosei Tanaka, Shintaro Tajima, Shinji Takenaka, Ken-ichi Yoshida

Abstract

Bacillus subtilis 168 possesses an efficient pathway to metabolize some of the stereoisomers of inositol, including myo-inositol (MI) and scyllo-inositol (SI). Previously we reported a prototype of a B. subtilis cell factory with modified inositol metabolism that converts MI into SI in the culture medium. However, it wasted half of initial 1.0% (w/v) MI, and the conversion was limited to produce only 0.4% (w/v) SI. To achieve a more efficient SI production, we attempted additional modifications.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 3%
India 1 3%
Unknown 29 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 23%
Student > Bachelor 5 16%
Researcher 5 16%
Student > Master 4 13%
Student > Doctoral Student 2 6%
Other 4 13%
Unknown 4 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 26%
Biochemistry, Genetics and Molecular Biology 6 19%
Medicine and Dentistry 4 13%
Nursing and Health Professions 2 6%
Engineering 2 6%
Other 5 16%
Unknown 4 13%