Title |
Differential in vivo expression of mycobacterial antigens in Mycobacterium tuberculosisinfected lungs and lymph node tissues
|
---|---|
Published in |
BMC Infectious Diseases, October 2014
|
DOI | 10.1186/1471-2334-14-535 |
Pubmed ID | |
Authors |
Tehmina Mustafa, Nils Anders Leversen, Lisbet Sviland, Harald Gotten Wiker |
Abstract |
The clinical course of tuberculosis (TB) infection, bacterial load and the morphology of lesions vary between pulmonary and extrapulmonary TB. Antigens expressed in abundance during infection could represent relevant antigens in the development of diagnostic tools, but little is known about the in vivo expression of various M. tuberculosis antigens in different clinical manifestations. The aim of this study was to study the differences in the presence of major secreted as well as somatic mycobacterial antigens in host tissues during advanced rapidly progressing and fatal pulmonary disease with mainly pneumonic infiltrates and high bacterial load, and to compare this to the presence of the same antigens in TB lymphadenitis cases, which is mainly chronic and self-limiting disease with organised granulomas and lower bacterial load. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Unknown | 45 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 17% |
Student > Doctoral Student | 8 | 17% |
Student > Bachelor | 6 | 13% |
Student > Master | 6 | 13% |
Student > Ph. D. Student | 5 | 11% |
Other | 8 | 17% |
Unknown | 5 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 26% |
Agricultural and Biological Sciences | 6 | 13% |
Immunology and Microbiology | 5 | 11% |
Nursing and Health Professions | 5 | 11% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Other | 9 | 20% |
Unknown | 7 | 15% |