Title |
Adipokines and Insulin Resistance
|
---|---|
Published in |
Molecular Medicine, November 2008
|
DOI | 10.2119/2008-00058.rabe |
Pubmed ID | |
Authors |
Katja Rabe, Michael Lehrke, Klaus G. Parhofer, Uli C. Broedl |
Abstract |
Obesity is associated with an array of health problems in adult and pediatric populations. Understanding the pathogenesis of obesity and its metabolic sequelae has advanced rapidly over the past decades. Adipose tissue represents an active endocrine organ that, in addition to regulating fat mass and nutrient homeostasis, releases a large number of bioactive mediators (adipokines) that signal to organs of metabolic importance including brain, liver, skeletal muscle, and the immune system--thereby modulating hemostasis, blood pressure, lipid and glucose metabolism, inflammation, and atherosclerosis. In the present review, we summarize current data on the effect of the adipose tissue-derived hormones adiponectin, chemerin, leptin, omentin, resistin, retinol binding protein 4, tumor necrosis factor-alpha and interleukin-6, vaspin, and visfatin on insulin resistance. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | <1% |
United States | 2 | <1% |
United Kingdom | 2 | <1% |
France | 1 | <1% |
Austria | 1 | <1% |
Netherlands | 1 | <1% |
India | 1 | <1% |
Guatemala | 1 | <1% |
Brazil | 1 | <1% |
Other | 4 | <1% |
Unknown | 410 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 79 | 19% |
Researcher | 60 | 14% |
Student > Master | 59 | 14% |
Student > Bachelor | 52 | 12% |
Other | 27 | 6% |
Other | 76 | 18% |
Unknown | 73 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 109 | 26% |
Agricultural and Biological Sciences | 99 | 23% |
Biochemistry, Genetics and Molecular Biology | 40 | 9% |
Sports and Recreations | 15 | 4% |
Nursing and Health Professions | 13 | 3% |
Other | 57 | 13% |
Unknown | 93 | 22% |