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tigaR: integrative significance analysis of temporal differential gene expression induced by genomic abnormalities

Overview of attention for article published in BMC Bioinformatics, October 2014
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Title
tigaR: integrative significance analysis of temporal differential gene expression induced by genomic abnormalities
Published in
BMC Bioinformatics, October 2014
DOI 10.1186/1471-2105-15-327
Pubmed ID
Authors

Viktorian Miok, Saskia M Wilting, Mark A van de Wiel, Annelieke Jaspers, Paula I van Noort, Ruud H Brakenhoff, Peter JF Snijders, Renske DM Steenbergen, Wessel N van Wieringen

Abstract

To determine which changes in the host cell genome are crucial for cervical carcinogenesis, a longitudinal in vitro model system of HPV-transformed keratinocytes was profiled in a genome-wide manner. Four cell lines affected with either HPV16 or HPV18 were assayed at 8 sequential time points for gene expression (mRNA) and gene copy number (DNA) using high-resolution microarrays. Available methods for temporal differential expression analysis are not designed for integrative genomic studies.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 4%
Sweden 1 4%
Unknown 26 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 25%
Researcher 6 21%
Student > Doctoral Student 2 7%
Professor 2 7%
Professor > Associate Professor 2 7%
Other 3 11%
Unknown 6 21%
Readers by discipline Count As %
Medicine and Dentistry 7 25%
Agricultural and Biological Sciences 6 21%
Biochemistry, Genetics and Molecular Biology 4 14%
Mathematics 2 7%
Computer Science 2 7%
Other 1 4%
Unknown 6 21%