Title |
The pathophysiological role of mitochondrial oxidative stress in lung diseases
|
---|---|
Published in |
Journal of Translational Medicine, October 2017
|
DOI | 10.1186/s12967-017-1306-5 |
Pubmed ID | |
Authors |
Xiaojing Liu, Zhihong Chen |
Abstract |
Mitochondria are critically involved in reactive oxygen species (ROS)-dependent lung diseases, such as lung fibrosis, asbestos, chronic airway diseases and lung cancer. Mitochondrial DNA (mtDNA) encodes mitochondrial proteins and is more sensitive to oxidants than nuclear DNA. Damage to mtDNA causes mitochondrial dysfunction, including electron transport chain impairment and mitochondrial membrane potential loss. Furthermore, damaged mtDNA also acts as a damage-associated molecular pattern (DAMP) that drives inflammatory and immune responses. In this review, crosstalk among alveolar epithelial cells, alveolar macrophages and mitochondria is examined. ROS-related transcription factors and downstream cell signaling pathways are also discussed. We conclude that targeting oxidative stress with antioxidant agents, such as thiol molecules, polyphenols and superoxide dismutase (SOD), and promoting mitochondrial biogenesis should be considered as novel strategies for treating lung diseases that currently have no effective treatment options. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 33% |
Australia | 1 | 17% |
France | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 50% |
Scientists | 2 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 154 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 30 | 19% |
Researcher | 19 | 12% |
Student > Master | 16 | 10% |
Student > Bachelor | 11 | 7% |
Student > Doctoral Student | 8 | 5% |
Other | 14 | 9% |
Unknown | 56 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 33 | 21% |
Medicine and Dentistry | 19 | 12% |
Agricultural and Biological Sciences | 11 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
Nursing and Health Professions | 3 | 2% |
Other | 21 | 14% |
Unknown | 60 | 39% |