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Expression of GBGT1 is epigenetically regulated by DNA methylation in ovarian cancer cells

Overview of attention for article published in BMC Molecular Biology, January 2014
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2 tweeters

Citations

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Readers on

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24 Mendeley
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Title
Expression of GBGT1 is epigenetically regulated by DNA methylation in ovarian cancer cells
Published in
BMC Molecular Biology, January 2014
DOI 10.1186/1471-2199-15-24
Pubmed ID
Authors

Francis Jacob, Megan P Hitchins, André Fedier, Kevin Brennan, Sheri Nixdorf, Neville F Hacker, Robyn Ward, Viola A Heinzelmann-Schwarz

Abstract

The GBGT1 gene encodes the globoside alpha-1,3-N-acetylgalactosaminyltransferase 1. This enzyme catalyzes the last step in the multi-step biosynthesis of the Forssman (Fs) antigen, a pentaglycosyl ceramide of the globo series glycosphingolipids. While differential GBGT1 mRNA expression has been observed in a variety of human tissues being highest in placenta and ovary, the expression of GBGT1 and the genes encoding the glycosyltransferases and glycosidases involved in the biosynthesis of Fs as well as the possible involvement of DNA methylation in transcriptional regulation of GBGT1 expression have not yet been investigated.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Russia 1 4%
Portugal 1 4%
Brazil 1 4%
Unknown 20 83%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 21%
Student > Master 4 17%
Researcher 3 13%
Student > Doctoral Student 2 8%
Student > Ph. D. Student 2 8%
Other 4 17%
Unknown 4 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 29%
Medicine and Dentistry 5 21%
Biochemistry, Genetics and Molecular Biology 4 17%
Nursing and Health Professions 2 8%
Unknown 6 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2014.
All research outputs
#16,603,226
of 21,321,698 outputs
Outputs from BMC Molecular Biology
#227
of 311 outputs
Outputs of similar age
#150,550
of 226,395 outputs
Outputs of similar age from BMC Molecular Biology
#1
of 1 outputs
Altmetric has tracked 21,321,698 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 311 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,395 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them