Title |
A cardiopulmonary bypass with deep hypothermic circulatory arrest rat model for the investigation of the systemic inflammation response and induced organ damage
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Published in |
Journal of Inflammation, August 2014
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DOI | 10.1186/s12950-014-0026-3 |
Pubmed ID | |
Authors |
Melanie Engels, Esra Bilgic, Antonio Pinto, Edwin Vasquez, Lena Wollschläger, Holger Steinbrenner, Kristine Kellermann, Payam Akhyari, Artur Lichtenberg, Udo Boeken |
Abstract |
Cardiopulmonary bypass (CPB) is a commonly used technique in cardiac surgery. CPB is however associated with a strong induction of systemic inflammatory response syndrome (SIRS) which in conjunction with ischemia and reperfusion may lead to multiple organ failure. The aim of the study was to establish and characterize a CPB rat model incorporating deep hypothermic circulatory arrest with a specific focus on the extent of the inflammatory reactions and organ damage as a groundwork for novel therapeutics against SIRS and I/R induced organ injury. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Canada | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 3% |
Unknown | 30 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 19% |
Researcher | 6 | 19% |
Student > Bachelor | 4 | 13% |
Other | 3 | 10% |
Student > Master | 3 | 10% |
Other | 6 | 19% |
Unknown | 3 | 10% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 24 | 77% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Engineering | 1 | 3% |
Unknown | 4 | 13% |