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Elevated autocrine EDIL3 protects hepatocellular carcinoma from anoikis through RGD-mediated integrin activation

Overview of attention for article published in Molecular Cancer, October 2014
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Title
Elevated autocrine EDIL3 protects hepatocellular carcinoma from anoikis through RGD-mediated integrin activation
Published in
Molecular Cancer, October 2014
DOI 10.1186/1476-4598-13-226
Pubmed ID
Authors

Ming-Xuan Feng, Ming-Ze Ma, Ying Fu, Jun Li, Tao Wang, Feng Xue, Jian-Jun Zhang, Wen-Xin Qin, Jian-Ren Gu, Zhi-Gang Zhang, Qiang Xia

Abstract

A remolded microenvironment in hepatocellular carcinoma (HCC) caused by abnormally expressed matricellular proteins could promote HCC progression. The cell-matrix interactions mediated by integrins play an important role in tumor microenvironment. Epidermal Growth Factor-like repeats and Discoidin I-Like Domains 3 (EDIL3), an extracellular matrix (ECM) protein with angiogenic and anti-inflammatory effects, is abnormally highly expressed in HCC. Here we aim to analyze its expression in liver and HCC tissues, investigate the underlined mechanisms accounted for HCC progression.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 24%
Student > Master 4 14%
Student > Ph. D. Student 3 10%
Student > Doctoral Student 2 7%
Lecturer 2 7%
Other 4 14%
Unknown 7 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 21%
Medicine and Dentistry 5 17%
Agricultural and Biological Sciences 3 10%
Neuroscience 2 7%
Immunology and Microbiology 2 7%
Other 5 17%
Unknown 6 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2015.
All research outputs
#17,728,987
of 22,766,595 outputs
Outputs from Molecular Cancer
#1,200
of 1,719 outputs
Outputs of similar age
#170,731
of 253,596 outputs
Outputs of similar age from Molecular Cancer
#28
of 36 outputs
Altmetric has tracked 22,766,595 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,719 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 253,596 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.