Title |
Elevated autocrine EDIL3 protects hepatocellular carcinoma from anoikis through RGD-mediated integrin activation
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Published in |
Molecular Cancer, October 2014
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DOI | 10.1186/1476-4598-13-226 |
Pubmed ID | |
Authors |
Ming-Xuan Feng, Ming-Ze Ma, Ying Fu, Jun Li, Tao Wang, Feng Xue, Jian-Jun Zhang, Wen-Xin Qin, Jian-Ren Gu, Zhi-Gang Zhang, Qiang Xia |
Abstract |
A remolded microenvironment in hepatocellular carcinoma (HCC) caused by abnormally expressed matricellular proteins could promote HCC progression. The cell-matrix interactions mediated by integrins play an important role in tumor microenvironment. Epidermal Growth Factor-like repeats and Discoidin I-Like Domains 3 (EDIL3), an extracellular matrix (ECM) protein with angiogenic and anti-inflammatory effects, is abnormally highly expressed in HCC. Here we aim to analyze its expression in liver and HCC tissues, investigate the underlined mechanisms accounted for HCC progression. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 24% |
Student > Master | 4 | 14% |
Student > Ph. D. Student | 3 | 10% |
Student > Doctoral Student | 2 | 7% |
Lecturer | 2 | 7% |
Other | 4 | 14% |
Unknown | 7 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 21% |
Medicine and Dentistry | 5 | 17% |
Agricultural and Biological Sciences | 3 | 10% |
Neuroscience | 2 | 7% |
Immunology and Microbiology | 2 | 7% |
Other | 5 | 17% |
Unknown | 6 | 21% |