Title |
Influence of insulin and glargine on outgrowth and number of circulating endothelial progenitor cells in type 2 diabetes patients: a partially double-blind, randomized, three-arm unicenter study
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Published in |
Cardiovascular Diabetology, October 2014
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DOI | 10.1186/s12933-014-0137-4 |
Pubmed ID | |
Authors |
Dimitrios Oikonomou, Stefan Kopf, Rüdiger von Bauer, Zdenka Djuric, Rita Cebola, Anja Sander, Stefan Englert, Spiros Vittas, Asa Hidmark, Michael Morcos, Grigorios Korosoglou, Peter P Nawroth, Per M Humpert |
Abstract |
Endothelial progenitor cells (EPC) are bone marrow-derived cells which can undergo differentiation into endothelial cells and participate in endothelial repair and angiogenesis. Insulin facilitates this in vitro mediated by the IGF-1 receptor. Clinical trials showed that the number of circulating EPCs is influenced by glucose control and EPC are a predictor of cardiovascular death. To study direct effects of insulin treatment on EPCs in type 2 diabetes patients, add-on basal insulin treatment was compared to an escalation of oral medication aiming at similar glucose control between the groups. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 1 | 2% |
Unknown | 65 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 13 | 20% |
Student > Bachelor | 11 | 17% |
Researcher | 9 | 14% |
Other | 6 | 9% |
Student > Postgraduate | 3 | 5% |
Other | 7 | 11% |
Unknown | 17 | 26% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 29 | 44% |
Biochemistry, Genetics and Molecular Biology | 5 | 8% |
Nursing and Health Professions | 4 | 6% |
Agricultural and Biological Sciences | 4 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 4 | 6% |
Unknown | 19 | 29% |