Title |
Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma
|
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Published in |
BMC Cancer, October 2014
|
DOI | 10.1186/1471-2407-14-752 |
Pubmed ID | |
Authors |
Emily R Theisen, Snehal Gajiwala, Jared Bearss, Venkataswamy Sorna, Sunil Sharma, Margit Janat-Amsbury |
Abstract |
Endometrial cancer is the most common gynecologic malignancy. Type II endometrial carcinoma is often poorly differentiated and patients diagnosed with Type II disease (~11%) are disproportionately represented in annual endometrial cancer deaths (48%). Recent genomic studies highlight mutations in chromatin regulators as drivers in Type II endometrial carcinoma tumorigenesis, suggesting the use of epigenetic targeted therapies could provide clinical benefit to these patients. We investigated the anti-tumor efficacy of the LSD1 inhibitor HCI2509 in two poorly differentiated Type II endometrial cancer cell lines AN3CA and KLE. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 50% |
India | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | 2% |
Denmark | 1 | 2% |
Unknown | 53 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 18% |
Other | 9 | 16% |
Researcher | 8 | 15% |
Student > Doctoral Student | 3 | 5% |
Student > Bachelor | 3 | 5% |
Other | 9 | 16% |
Unknown | 13 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 14 | 25% |
Medicine and Dentistry | 9 | 16% |
Agricultural and Biological Sciences | 8 | 15% |
Chemistry | 4 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Other | 2 | 4% |
Unknown | 15 | 27% |