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Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma

Overview of attention for article published in BMC Cancer, October 2014
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Title
Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma
Published in
BMC Cancer, October 2014
DOI 10.1186/1471-2407-14-752
Pubmed ID
Authors

Emily R Theisen, Snehal Gajiwala, Jared Bearss, Venkataswamy Sorna, Sunil Sharma, Margit Janat-Amsbury

Abstract

Endometrial cancer is the most common gynecologic malignancy. Type II endometrial carcinoma is often poorly differentiated and patients diagnosed with Type II disease (~11%) are disproportionately represented in annual endometrial cancer deaths (48%). Recent genomic studies highlight mutations in chromatin regulators as drivers in Type II endometrial carcinoma tumorigenesis, suggesting the use of epigenetic targeted therapies could provide clinical benefit to these patients. We investigated the anti-tumor efficacy of the LSD1 inhibitor HCI2509 in two poorly differentiated Type II endometrial cancer cell lines AN3CA and KLE.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 2%
Denmark 1 2%
Unknown 53 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 18%
Other 9 16%
Researcher 8 15%
Student > Doctoral Student 3 5%
Student > Bachelor 3 5%
Other 9 16%
Unknown 13 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 25%
Medicine and Dentistry 9 16%
Agricultural and Biological Sciences 8 15%
Chemistry 4 7%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 2 4%
Unknown 15 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 November 2014.
All research outputs
#17,728,987
of 22,766,595 outputs
Outputs from BMC Cancer
#4,956
of 8,278 outputs
Outputs of similar age
#171,784
of 255,208 outputs
Outputs of similar age from BMC Cancer
#106
of 164 outputs
Altmetric has tracked 22,766,595 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,278 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,208 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 164 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.