Title |
T-tubule biogenesis and triad formation in skeletal muscle and implication in human diseases
|
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Published in |
Skeletal Muscle, July 2011
|
DOI | 10.1186/2044-5040-1-26 |
Pubmed ID | |
Authors |
Lama Al-Qusairi, Jocelyn Laporte |
Abstract |
In skeletal muscle, the excitation-contraction (EC) coupling machinery mediates the translation of the action potential transmitted by the nerve into intracellular calcium release and muscle contraction. EC coupling requires a highly specialized membranous structure, the triad, composed of a central T-tubule surrounded by two terminal cisternae from the sarcoplasmic reticulum. While several proteins located on these structures have been identified, mechanisms governing T-tubule biogenesis and triad formation remain largely unknown. Here, we provide a description of triad structure and plasticity and review the role of proteins that have been linked to T-tubule biogenesis and triad formation and/or maintenance specifically in skeletal muscle: caveolin 3, amphiphysin 2, dysferlin, mitsugumins, junctophilins, myotubularin, ryanodine receptor, and dihydhropyridine Receptor. The importance of these proteins in triad biogenesis and subsequently in muscle contraction is sustained by studies on animal models and by the direct implication of most of these proteins in human myopathies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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France | 2 | <1% |
United States | 2 | <1% |
Chile | 1 | <1% |
Korea, Republic of | 1 | <1% |
Sweden | 1 | <1% |
Ireland | 1 | <1% |
Mexico | 1 | <1% |
United Kingdom | 1 | <1% |
Unknown | 237 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 54 | 22% |
Student > Bachelor | 33 | 13% |
Student > Master | 30 | 12% |
Researcher | 24 | 10% |
Professor > Associate Professor | 12 | 5% |
Other | 37 | 15% |
Unknown | 57 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 66 | 27% |
Biochemistry, Genetics and Molecular Biology | 54 | 22% |
Medicine and Dentistry | 32 | 13% |
Neuroscience | 9 | 4% |
Engineering | 4 | 2% |
Other | 19 | 8% |
Unknown | 63 | 26% |