Title |
RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus
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Published in |
BMC Genomics, October 2014
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DOI | 10.1186/1471-2164-15-894 |
Pubmed ID | |
Authors |
Grainne O’Keeffe, Stephen Hammel, Rebecca A Owens, Thomas M Keane, David A Fitzpatrick, Gary W Jones, Sean Doyle |
Abstract |
Aspergillus fumigatus produces a number of secondary metabolites, one of which, gliotoxin, has been shown to exhibit anti-fungal activity. Thus, A. fumigatus must be able to protect itself against gliotoxin. Indeed one of the genes in the gliotoxin biosynthetic gene cluster in A. fumigatus, gliT, is required for self-protection against the toxin- however the global self-protection mechanism deployed is unclear. RNA-seq was employed to identify genes differentially regulated upon exposure to gliotoxin in A. fumigatus wild-type and A. fumigatus ∆gliT, a strain that is hypersensitive to gliotoxin. |
X Demographics
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United States | 1 | 50% |
France | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Colombia | 1 | 2% |
Unknown | 56 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 20 | 35% |
Researcher | 10 | 18% |
Student > Bachelor | 4 | 7% |
Student > Master | 4 | 7% |
Student > Postgraduate | 3 | 5% |
Other | 8 | 14% |
Unknown | 8 | 14% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 31 | 54% |
Biochemistry, Genetics and Molecular Biology | 7 | 12% |
Immunology and Microbiology | 4 | 7% |
Medicine and Dentistry | 2 | 4% |
Computer Science | 1 | 2% |
Other | 1 | 2% |
Unknown | 11 | 19% |