Title |
Large cell neuroendocrine carcinoma of the ovary: a case report and a brief review of the literature
|
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Published in |
World Journal of Surgical Oncology, October 2014
|
DOI | 10.1186/1477-7819-12-314 |
Pubmed ID | |
Authors |
Eun Young Ki, Jong Sup Park, Keun Ho Lee, Seog Nyeon Bae, Soo Young Hur |
Abstract |
Large cell neuroendocrine carcinoma (LCNC) of the ovary, or ovarian undifferentiated non-small cell carcinoma of neuroendocrine type, is a rare entity that is frequently associated with ovarian surface epithelial tumors. Few cases have been reported in the literature. LCNC is an aggressive tumor with tendency to present at advanced stages and to cause death after a short postoperative duration. We report three cases of LCNC diagnosed histopathologically. Immunohistochemically, the tumor cells were positive for chromogranin A, NSE, CD56, and pancytokeratin. The patients were treated postoperatively with combination chemotherapy. Due to the rarity of LCNC, the general consensus on standard therapy is not established. Although most patients are at stage I, the biological aggressiveness and poor prognosis of the tumors have been reported in previous reports despite extensive surgery and chemotherapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Scientists | 1 | 33% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Italy | 1 | 14% |
Unknown | 6 | 86% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 2 | 29% |
Student > Bachelor | 1 | 14% |
Student > Master | 1 | 14% |
Unknown | 3 | 43% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 2 | 29% |
Economics, Econometrics and Finance | 1 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 14% |
Unknown | 3 | 43% |