Title |
The risk of elevated prolactin levels in pediatric patients exposed to antipsychotics for the treatment of schizophrenia and schizophrenia spectrum disorders: protocol for a systematic review and meta-analysis
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Published in |
Systematic Reviews, October 2014
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DOI | 10.1186/2046-4053-3-116 |
Pubmed ID | |
Authors |
Eric Druyts, Shawn Eapen, Ping Wu, Kristian Thorlund |
Abstract |
Antipsychotic medications, particularly second-generation antipsychotics, are increasingly being used to alleviate the symptoms of schizophrenia and other severe mental disorders in the pediatric population. While evidence-based approaches examining efficacy and safety outcomes have been reported, no review has evaluated prolactin-based adverse events for antipsychotic treatments in schizophrenia and schizophrenia spectrum disorders.Methods/design: Searches involving MEDLINE, EMBASE, CENTRAL, PsycINFO, and clinical trial registries (ClinicalTrials.gov, Drug Industry Document Archive [DIDA], International Clinical Trials Registry Platform [ICTRP]) will be used to identify relevant studies. Two reviewers will independently screen abstracts and relevant full-text articles of the papers identified by the initial search according to the prospectively defined eligibility criteria. Data extraction will be conducted in duplicate independently. Pairwise random effects meta-analyses and network meta-analyses will be conducted on individual drug and class effects where appropriate. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 53 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 11 | 21% |
Student > Bachelor | 6 | 11% |
Researcher | 6 | 11% |
Student > Ph. D. Student | 6 | 11% |
Other | 5 | 9% |
Other | 12 | 23% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 30% |
Biochemistry, Genetics and Molecular Biology | 4 | 8% |
Economics, Econometrics and Finance | 4 | 8% |
Nursing and Health Professions | 4 | 8% |
Social Sciences | 4 | 8% |
Other | 13 | 25% |
Unknown | 8 | 15% |