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The distribution of insertionally polymorphic endogenous retroviruses in breast cancer patients and cancer-free controls

Overview of attention for article published in Retrovirology, August 2014
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Title
The distribution of insertionally polymorphic endogenous retroviruses in breast cancer patients and cancer-free controls
Published in
Retrovirology, August 2014
DOI 10.1186/s12977-014-0062-3
Pubmed ID
Authors

Julia H Wildschutte, Daniel Ram, Ravi Subramanian, Victoria L Stevens, John M Coffin

Abstract

Integration of retroviral DNA into a germ cell can result in a provirus that is transmitted vertically to the host's offspring. In humans, such endogenous retroviruses (HERVs) comprise >8% of the genome. The HERV-K(HML-2) proviruses consist of ~90 elements related to mouse mammary tumor virus, which causes breast cancer in mice. A subset of HERV-K(HML-2) proviruses has some or all genes intact, and even encodes functional proteins, though a replication competent copy has yet to be observed. More than 10% of HML-2 proviruses are human-specific, having integrated subsequent to the Homo-Pan divergence, and, of these, 11 are currently known to be polymorphic in integration site with variable frequencies among individuals. Increased expression of the most recent HML-2 proviruses has been observed in tissues and cell lines from several types of cancer, including breast cancer, for which expression may provide a meaningful marker of the disease.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 2%
Brazil 1 2%
Unknown 51 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 19%
Researcher 9 17%
Student > Bachelor 8 15%
Student > Master 7 13%
Student > Doctoral Student 4 8%
Other 6 11%
Unknown 9 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 34%
Biochemistry, Genetics and Molecular Biology 9 17%
Medicine and Dentistry 8 15%
Immunology and Microbiology 5 9%
Computer Science 1 2%
Other 2 4%
Unknown 10 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2014.
All research outputs
#18,380,628
of 22,766,595 outputs
Outputs from Retrovirology
#955
of 1,106 outputs
Outputs of similar age
#164,847
of 231,115 outputs
Outputs of similar age from Retrovirology
#11
of 11 outputs
Altmetric has tracked 22,766,595 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,106 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,115 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.