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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Heparin therapy reduces 28-day mortality in adult severe sepsis patients: a systematic review and meta-analysis
|
|---|---|
| Published in |
Critical Care, October 2014
|
| DOI | 10.1186/s13054-014-0563-4 |
| Pubmed ID | |
| Authors |
Changsong Wang, Chunjie Chi, Lei Guo, Xiaoyang Wang, Libo Guo, Jiaxiao Sun, Bo Sun, Shanshan Liu, Xuenan Chang, Enyou Li |
| Abstract |
IntroductionThere are approximately 19 million new cases of sepsis worldwide each year. Among them, more than one-quarter of patients die. We aimed to assess the effects of heparin on short term mortality in adult patients with sepsis and severe sepsis.MethodsWe searched electronic databases (Medline, Embase, and Cochrane Library databases; the Cochrane Controlled Trials Register) and conference proceedings (Web of Knowledge (Conference Proceedings Citation Index - Science, Conference Proceedings Citation Index - Social Sciences & Humanities)) from inception to July 2014, expert contacts and relevant websites. Controlled trials of heparin versus placebo in sepsis or severe sepsis were identified. In total 2 reviewers independently assessed eligibility, and 4 authors independently extracted data; consensus was reached by conference. We used the chi-square test and I2 to assess statistical heterogeneity (P <0.05). The primary analysis was based on the fixed effects model to produce pooled odds ratios with 95% confidence intervals.ResultsA total of 9 publications were included in the meta-analysis. Heparin decreased 28-day mortality (n¿=¿3482, OR¿=¿0.656, 95% CI¿=¿0.562 to 0.765, P <0.0001). According to the meta-analysis of 28-day mortality, heterogeneity was not found among the 8 randomized clinical trials (RCTs) (I2¿=¿0.0%). Heparin had no effect on bleeding events in sepsis (7 RCTs, n¿=¿2726; OR¿=¿1.063; 95% CI¿=¿0.834 to 1.355; P¿=¿0.623; and I2¿=¿20.9%). Subgroup analysis demonstrated that the sample size may be a source of heterogeneity, but experimental design was not.ConclusionsHeparin may reduce 28-day mortality in patients with severe sepsis, at the same time, there was no increase in the risk of bleeding in the heparin group. We recommend the use of heparin for sepsis and severe sepsis. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 11% |
| Chile | 1 | 5% |
| Italy | 1 | 5% |
| Canada | 1 | 5% |
| Kuwait | 1 | 5% |
| Ecuador | 1 | 5% |
| United Kingdom | 1 | 5% |
| Unknown | 11 | 58% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 68% |
| Practitioners (doctors, other healthcare professionals) | 3 | 16% |
| Science communicators (journalists, bloggers, editors) | 2 | 11% |
| Scientists | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 3% |
| United States | 1 | 2% |
| Denmark | 1 | 2% |
| Colombia | 1 | 2% |
| Unknown | 56 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 13% |
| Student > Ph. D. Student | 7 | 11% |
| Student > Bachelor | 7 | 11% |
| Student > Master | 6 | 10% |
| Student > Doctoral Student | 4 | 7% |
| Other | 15 | 25% |
| Unknown | 14 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 28 | 46% |
| Biochemistry, Genetics and Molecular Biology | 5 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
| Agricultural and Biological Sciences | 3 | 5% |
| Immunology and Microbiology | 2 | 3% |
| Other | 4 | 7% |
| Unknown | 15 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2015.
All research outputs
#2,730,229
of 25,374,647 outputs
Outputs from Critical Care
#2,361
of 6,554 outputs
Outputs of similar age
#30,487
of 268,233 outputs
Outputs of similar age from Critical Care
#26
of 145 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,233 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 145 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.