Title |
Phenotypic and functional evaluations of peripheral blood monocytes from chronic-form paracoccidioidomycosis patients before and after treatment
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Published in |
BMC Infectious Diseases, October 2014
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DOI | 10.1186/s12879-014-0552-x |
Pubmed ID | |
Authors |
James Venturini, Ricardo Souza Cavalcante, Márjorie de Assis Golim, Camila Martins Marchetti, Priscila Zacarias de Azevedo, Bárbara Casella Amorim, Maria Sueli Parreira de Arruda, Rinaldo Poncio Mendes |
Abstract |
Paracoccidioidomycosis (PCM) is systemic mycosis caused by the thermal dimorphic fungus of genus Paracoccidioides, leading to either acute/subacute (AF) or chronic (CF) clinical forms. Numerous CF patients after treatment exhibit sequels, such as pulmonary and adrenal fibrosis. Monocytes are cells that are involved in the inflammatory response during active infection as well as in the fibrogenesis. These cells comprise a heterogeneous population with distinct phenotypic and functional activities. The scope of this study was to identify changes regarding functional and phenotypical aspects in monocytes comparing CF PCM patients on antifungal treatment versus non-treated patients (PMC-p). |
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Geographical breakdown
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 4 | 17% |
Student > Ph. D. Student | 4 | 17% |
Student > Postgraduate | 4 | 17% |
Student > Master | 2 | 8% |
Student > Bachelor | 1 | 4% |
Other | 3 | 13% |
Unknown | 6 | 25% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 7 | 29% |
Agricultural and Biological Sciences | 5 | 21% |
Medicine and Dentistry | 3 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Other | 1 | 4% |
Unknown | 6 | 25% |