Title |
Primary immunodeficiency in infection-prone children in southern Sweden: occurrence, clinical characteristics and immunological findings
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Published in |
BMC Immunology, August 2014
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DOI | 10.1186/s12865-014-0031-6 |
Pubmed ID | |
Authors |
Nicholas Brodszki, Göran Jönsson, Lillemor Skattum, Lennart Truedsson |
Abstract |
Primary immunodeficiency diseases (PIDs) comprise a heterogeneous group of disorders mainly characterized by increased susceptibility to infections. The aims of this study were to estimate the occurrence rate of PID in the paediatric (age ≤ 18 years) population of southern Sweden (approx. 265,000 children) and to describe their demographic, clinical and immunological characteristics. During a period of 4 years, in four paediatric speciality clinics in Skåne County in southern Sweden, children being seen for infections and fulfilling specific criteria were evaluated according to a predefined examination schedule. The initial analysis consisted of complete blood counts with analysis of lymphocyte subpopulations (T, B, NK cells), measurement of immunoglobulins (IgG, IgA, IgM, IgE and IgG subclasses), and assessment of the complement system (classical, alternative and lectin pathways). In addition, results of these immunological analyses in other children from the same area and time period were evaluated. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 47 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 15% |
Student > Bachelor | 7 | 15% |
Researcher | 6 | 13% |
Other | 5 | 11% |
Student > Master | 4 | 9% |
Other | 11 | 23% |
Unknown | 7 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 27 | 57% |
Immunology and Microbiology | 2 | 4% |
Agricultural and Biological Sciences | 2 | 4% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Mathematics | 1 | 2% |
Other | 2 | 4% |
Unknown | 12 | 26% |