Title |
Epitranscriptomic influences on development and disease
|
---|---|
Published in |
Genome Biology, October 2017
|
DOI | 10.1186/s13059-017-1336-6 |
Pubmed ID | |
Authors |
Phillip J. Hsu, Hailing Shi, Chuan He |
Abstract |
RNA contains over 150 types of chemical modifications. Although many of these chemical modifications were discovered several decades ago, their functions were not immediately apparent. Discoveries of RNA demethylases, along with advances in mass spectrometry and high-throughput sequencing techniques, have caused research into RNA modifications to progress at an accelerated rate. Post-transcriptional RNA modifications make up an epitranscriptome that extensively regulates gene expression and biological processes. Here, we present an overview of recent advances in the field that are shaping our understanding of chemical modifications, their impact on development and disease, and the dynamic mechanisms through which they regulate gene expression. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 8 | 53% |
Luxembourg | 1 | 7% |
United Kingdom | 1 | 7% |
Unknown | 5 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 9 | 60% |
Members of the public | 5 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 112 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 22 | 20% |
Researcher | 21 | 19% |
Student > Master | 15 | 13% |
Student > Bachelor | 10 | 9% |
Student > Doctoral Student | 5 | 4% |
Other | 14 | 13% |
Unknown | 25 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 43 | 38% |
Agricultural and Biological Sciences | 15 | 13% |
Medicine and Dentistry | 8 | 7% |
Chemistry | 5 | 4% |
Neuroscience | 4 | 4% |
Other | 11 | 10% |
Unknown | 26 | 23% |