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Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol

Overview of attention for article published in Genome Biology, September 2001
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

Mentioned by

blogs
1 blog

Citations

dimensions_citation
318 Dimensions

Readers on

mendeley
148 Mendeley
citeulike
2 CiteULike
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Title
Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol
Published in
Genome Biology, September 2001
DOI 10.1186/gb-2001-2-10-research0041
Pubmed ID
Authors

Lloyd T Lam, Oxana K Pickeral, Amy C Peng, Andreas Rosenwald, Elaine M Hurt, Jena M Giltnane, Lauren M Averett, Hong Zhao, R Eric Davis, Mohan Sathyamoorthy, Larry M Wahl, Eric D Harris, Judy A Mikovits, Anne P Monks, Melinda G Hollingshead, Edward A Sausville, Louis M Staudt

Abstract

Flavopiridol, a flavonoid currently in cancer clinical trials, inhibits cyclin-dependent kinases (CDKs) by competitively blocking their ATP-binding pocket. However, the mechanism of action of flavopiridol as an anti-cancer agent has not been fully elucidated.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 3%
United Kingdom 1 <1%
Brazil 1 <1%
Canada 1 <1%
Poland 1 <1%
Unknown 140 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 33 22%
Researcher 27 18%
Student > Master 15 10%
Student > Bachelor 14 9%
Other 10 7%
Other 24 16%
Unknown 25 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 53 36%
Biochemistry, Genetics and Molecular Biology 33 22%
Medicine and Dentistry 15 10%
Immunology and Microbiology 3 2%
Chemistry 3 2%
Other 11 7%
Unknown 30 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2011.
All research outputs
#6,427,183
of 25,374,647 outputs
Outputs from Genome Biology
#3,084
of 4,467 outputs
Outputs of similar age
#12,433
of 42,533 outputs
Outputs of similar age from Genome Biology
#8
of 25 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 42,533 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.