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Mendeley readers
| Title |
Controlled delivery of BID protein fused with TAT peptide sensitizes cancer cells to apoptosis
|
|---|---|
| Published in |
BMC Cancer, October 2014
|
| DOI | 10.1186/1471-2407-14-771 |
| Pubmed ID | |
| Authors |
Emilia Joanna Orzechowska, Ewa Kozlowska, Alicja Czubaty, Piotr Kozlowski, Krzysztof Staron, Joanna Trzcinska-Danielewicz |
| Abstract |
Low cellular level of BID is critical for viability of numerous cancer cells. Sensitization of cells to anticancer agents by BID overexpression from adenovirus or pcDNA vectors is a proposed strategy for cancer therapy; however it does not provide any stringent control of cellular level of BID. The aim of this work was to examine whether a fusion of BID with TAT cell penetrating peptide (TAT-BID) may be used for controlled sensitization of cancer cells to anticancer agents acting through death receptors (TRAIL) or DNA damage (camptothecin). Prostate cancer PC3 and LNCaP, non-small human lung cancer A549, and cervix carcinoma HeLa cells were used in the study. |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Poland | 1 | 3% |
| Unknown | 36 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 38% |
| Student > Bachelor | 6 | 16% |
| Student > Master | 6 | 16% |
| Lecturer | 1 | 3% |
| Professor | 1 | 3% |
| Other | 4 | 11% |
| Unknown | 5 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 32% |
| Biochemistry, Genetics and Molecular Biology | 8 | 22% |
| Medicine and Dentistry | 3 | 8% |
| Immunology and Microbiology | 2 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
| Other | 4 | 11% |
| Unknown | 6 | 16% |