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Receptor‐type protein tyrosine phosphatases in cancer

Overview of attention for article published in Cancer Communications, October 2014
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Title
Receptor‐type protein tyrosine phosphatases in cancer
Published in
Cancer Communications, October 2014
DOI 10.5732/cjc.014.10146
Pubmed ID
Authors

Yu Du, Jennifer R. Grandis

Abstract

Protein tyrosine phosphatases (PTPs) play an important role in regulating cell signaling events in coordination with tyrosine kinases to control cell proliferation, apoptosis, survival, migration, and invasion. Receptor-type protein tyrosine phosphatases (PTPRs) are a subgroup of PTPs that share a transmembrane domain with resulting similarities in function and target specificity. In this review, we summarize genetic and epigenetic alterations including mutation, deletion, amplification, and promoter methylation of PTPRs in cancer and consider the consequences of PTPR alterations in different type of cancers. We also summarize recent developments using PTPRs as prognostic or predictive biomarkers and/or direct targets. Increased understanding of the role of PTPRs in cancer may provide opportunities to improve therapeutic approaches.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 1%
Unknown 81 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 21%
Student > Master 15 18%
Student > Bachelor 13 16%
Researcher 8 10%
Student > Doctoral Student 7 9%
Other 6 7%
Unknown 16 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 19 23%
Medicine and Dentistry 17 21%
Agricultural and Biological Sciences 15 18%
Chemistry 4 5%
Immunology and Microbiology 2 2%
Other 7 9%
Unknown 18 22%