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Receptor-type protein tyrosine phosphatases in cancer

Overview of attention for article published in Ai zheng Aizheng Chinese journal of cancer, February 2015
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2 tweeters

Citations

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75 Mendeley
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Title
Receptor-type protein tyrosine phosphatases in cancer
Published in
Ai zheng Aizheng Chinese journal of cancer, February 2015
DOI 10.5732/cjc.014.10146
Pubmed ID
Authors

Yu Du, Jennifer R. Grandis

Abstract

Protein tyrosine phosphatases (PTPs) play an important role in regulating cell signaling events in coordination with tyrosine kinases to control cell proliferation, apoptosis, survival, migration, and invasion. Receptor-type protein tyrosine phosphatases (PTPRs) are a subgroup of PTPs that share a transmembrane domain with resulting similarities in function and target specificity. In this review, we summarize genetic and epigenetic alterations including mutation, deletion, amplification, and promoter methylation of PTPRs in cancer and consider the consequences of PTPR alterations in different type of cancers. We also summarize recent developments using PTPRs as prognostic or predictive biomarkers and/or direct targets. Increased understanding of the role of PTPRs in cancer may provide opportunities to improve therapeutic approaches.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 1%
Unknown 74 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 23%
Student > Master 15 20%
Student > Bachelor 12 16%
Researcher 8 11%
Student > Doctoral Student 6 8%
Other 8 11%
Unknown 9 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 18 24%
Medicine and Dentistry 17 23%
Agricultural and Biological Sciences 16 21%
Chemistry 4 5%
Arts and Humanities 1 1%
Other 7 9%
Unknown 12 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 October 2014.
All research outputs
#18,380,628
of 22,766,595 outputs
Outputs from Ai zheng Aizheng Chinese journal of cancer
#190
of 264 outputs
Outputs of similar age
#256,438
of 352,096 outputs
Outputs of similar age from Ai zheng Aizheng Chinese journal of cancer
#8
of 9 outputs
Altmetric has tracked 22,766,595 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 264 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,096 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one.