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Effectiveness of lithium in subjects with treatment-resistant depression and suicide risk: results and lessons of an underpowered randomised clinical trial

Overview of attention for article published in BMC Research Notes, October 2014
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

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103 Mendeley
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Title
Effectiveness of lithium in subjects with treatment-resistant depression and suicide risk: results and lessons of an underpowered randomised clinical trial
Published in
BMC Research Notes, October 2014
DOI 10.1186/1756-0500-7-731
Pubmed ID
Authors

Francesca Girlanda, Andrea Cipriani, Emilia Agrimi, Maria Grazia Appino, Andrea Barichello, Rossella Beneduce, Irene Bighelli, Giulia Bisoffi, Alfredo Bisogno, Paola Bortolaso, Marianna Boso, Carmela Calandra, Liliana Cascone, Mariasole Castellazzi, Caterina Corbascio, Vincenzo Fricchione Parise, Francesco Gardellin, Daniele Gennaro, Batul Hanife, Camilla Lintas, Marina Lorusso, Antonina Luca, Maria Luca, Chiara Luchetta, Claudio Lucii, Francesca Maio, Alessandra Marsilio, Chiara Mattei, Daniele Moretti, Michela Nosè, Guglielmo Occhionero, Duccio Papanti, Damiano Pecile, Mauro Percudani, Davide Prestia, Marianna Purgato, Francesco Restaino, Salvatore Romeo, Tiziana Sciarma, Stefania Strizzolo, Stefania Tamborini, Orlando Todarello, Fiorella Tozzi, Simona Ziero, Spyridon Zotos, Corrado Barbui

Abstract

As lithium treatment might be effective in reducing the risk of deliberate self-harm (DSH) in adult patients with unipolar affective disorders, we designed a pragmatic randomised trial to assess its efficacy in more than 200 patients with treatment-resistant depression. However, we randomised 56 patients only. The aim of this report is therefore twofold: first, to disseminate the results of this underpowered study which may be incorporated into future meta-analytical reviews; second, to analyse some critical aspects of the study which might explain failure to reach the target sample size.

X Demographics

X Demographics

The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 102 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 14%
Student > Doctoral Student 11 11%
Student > Bachelor 10 10%
Student > Ph. D. Student 9 9%
Other 8 8%
Other 25 24%
Unknown 26 25%
Readers by discipline Count As %
Medicine and Dentistry 23 22%
Psychology 22 21%
Nursing and Health Professions 6 6%
Social Sciences 5 5%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Other 10 10%
Unknown 34 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 October 2014.
All research outputs
#3,867,123
of 24,307,517 outputs
Outputs from BMC Research Notes
#526
of 4,378 outputs
Outputs of similar age
#42,524
of 263,286 outputs
Outputs of similar age from BMC Research Notes
#12
of 135 outputs
Altmetric has tracked 24,307,517 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,378 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,286 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 135 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.