Title |
SPARC mediates metastatic cooperation between CSC and non-CSC prostate cancer cell subpopulations
|
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Published in |
Molecular Cancer, October 2014
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DOI | 10.1186/1476-4598-13-237 |
Pubmed ID | |
Authors |
Francesca Mateo, Óscar Meca-Cortés, Toni Celià-Terrassa, Yolanda Fernández, Ibane Abasolo, Lourdes Sánchez-Cid, Raquel Bermudo, Amaia Sagasta, Leonardo Rodríguez-Carunchio, Mònica Pons, Verónica Cánovas, Mercedes Marín-Aguilera, Lourdes Mengual, Antonio Alcaraz, Simó Schwartz, Begoña Mellado, Kristina Y Aguilera, Rolf Brekken, Pedro L Fernández, Rosanna Paciucci, Timothy M Thomson |
Abstract |
Tumor cell subpopulations can either compete with each other for nutrients and physical space within the tumor niche, or co-operate for enhanced survival, or replicative or metastatic capacities. Recently, we have described co-operative interactions between two clonal subpopulations derived from the PC-3 prostate cancer cell line, in which the invasiveness of a cancer stem cell (CSC)-enriched subpopulation (PC-3M, or M) is enhanced by a non-CSC subpopulation (PC-3S, or S), resulting in their accelerated metastatic dissemination. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 13% |
Spain | 1 | 13% |
Romania | 1 | 13% |
Unknown | 5 | 63% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 38% |
Science communicators (journalists, bloggers, editors) | 2 | 25% |
Practitioners (doctors, other healthcare professionals) | 2 | 25% |
Scientists | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Germany | 1 | 1% |
Unknown | 85 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 21 | 24% |
Student > Ph. D. Student | 16 | 18% |
Student > Bachelor | 14 | 16% |
Other | 7 | 8% |
Student > Master | 7 | 8% |
Other | 12 | 14% |
Unknown | 10 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 25 | 29% |
Biochemistry, Genetics and Molecular Biology | 21 | 24% |
Medicine and Dentistry | 15 | 17% |
Engineering | 2 | 2% |
Immunology and Microbiology | 1 | 1% |
Other | 9 | 10% |
Unknown | 14 | 16% |