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Lipid metabolism fattens up hedgehog signaling

Overview of attention for article published in BMC Biology, October 2017
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7 X users

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Title
Lipid metabolism fattens up hedgehog signaling
Published in
BMC Biology, October 2017
DOI 10.1186/s12915-017-0442-y
Pubmed ID
Authors

Robert Blassberg, John Jacob

Abstract

Signaling pathways direct organogenesis, often through concentration-dependent effects on cells. The hedgehog pathway enables cells to sense and respond to hedgehog ligands, of which the best studied is sonic hedgehog. Hedgehog signaling is essential for development, proliferation, and stem cell maintenance, and it is a driver of certain cancers. Lipid metabolism has a profound influence on both hedgehog signal transduction and the properties of the ligands themselves, leading to changes in the strength of hedgehog signaling and cellular functions. Here we review the evolving understanding of the relationship between lipids and hedgehog signaling.

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The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 76 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 20%
Student > Ph. D. Student 8 11%
Student > Master 7 9%
Student > Doctoral Student 6 8%
Professor > Associate Professor 5 7%
Other 11 14%
Unknown 24 32%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 20 26%
Agricultural and Biological Sciences 11 14%
Neuroscience 7 9%
Medicine and Dentistry 3 4%
Immunology and Microbiology 2 3%
Other 5 7%
Unknown 28 37%