Title |
Preliminary evaluation of urinary soluble Met as a Biomarker for urothelial carcinoma of the bladder
|
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Published in |
Journal of Translational Medicine, October 2014
|
DOI | 10.1186/1479-5876-12-199 |
Pubmed ID | |
Authors |
Brian K McNeil, Maximiliano Sorbellini, Robert L Grubb, Andrea B Apolo, Fabiola Cecchi, Gagani Athauda, Benjamin Cohen, Alessio Giubellino, Haley Simpson, Piyush K Agarwal, Jonathan Coleman, Robert H Getzenberg, George J Netto, Joanna Shih, W Marston Linehan, Peter A Pinto, Donald P Bottaro |
Abstract |
Among genitourinary malignancies, bladder cancer (BCa) ranks second in both prevalence and cause of death. Biomarkers of BCa for diagnosis, prognosis and disease surveillance could potentially help prevent progression, improve survival rates and reduce health care costs. Among several oncogenic signaling pathways implicated in BCa progression is that of hepatocyte growth factor (HGF) and its cell surface receptor, Met, now targeted by 25 experimental anti-cancer agents in human clinical trials. The involvement of this pathway in several cancers is likely to preclude the use of urinary soluble Met (sMet), which has been correlated with malignancy, for initial BCa screening. However, its potential utility as an aid to disease surveillance and to identify patients likely to benefit from HGF/Met-targeted therapies provide the rationale for this preliminary retrospective study comparing sMet levels between benign conditions and primary BCa, and in BCa cases, between different disease stages. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 18% |
Student > Master | 3 | 14% |
Student > Bachelor | 2 | 9% |
Student > Ph. D. Student | 2 | 9% |
Student > Doctoral Student | 1 | 5% |
Other | 3 | 14% |
Unknown | 7 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 23% |
Biochemistry, Genetics and Molecular Biology | 3 | 14% |
Nursing and Health Professions | 2 | 9% |
Business, Management and Accounting | 1 | 5% |
Economics, Econometrics and Finance | 1 | 5% |
Other | 3 | 14% |
Unknown | 7 | 32% |