Title |
Screening the anti infectivity potentials of native N- and C-lobes derived from the camel lactoferrin against hepatitis C virus
|
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Published in |
BMC Complementary Medicine and Therapies, July 2014
|
DOI | 10.1186/1472-6882-14-219 |
Pubmed ID | |
Authors |
Elrashdy M Redwan, Esmail M EL-Fakharany, Vladimir N Uversky, Mustafa H Linjawi |
Abstract |
Hepatitis C virus (HCV) infection represents a worldwide health threat that still needs efficient protective vaccine and/or effective drug. The traditional medicine, such as camel milk, is heavily used by the large sector of HCV patients to control the infection due to the high cost of the available standard therapy. Camel milk contains lactoferrin, which plays an important and multifunctional role in innate immunity and specific host defense against microbial infection. Continuing the analysis of the effectiveness of camel lactoferrin against HCV, the current study aimed to separate and purify the native N- and C-lobes from the proteolytically cleaved camel lactoferrin (cLF) and to compare their in vitro activities against the HCV infection in Huh7.5 cells in order to determine the most active domain. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 49 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 14% |
Researcher | 5 | 10% |
Student > Master | 4 | 8% |
Student > Doctoral Student | 3 | 6% |
Student > Bachelor | 3 | 6% |
Other | 8 | 16% |
Unknown | 19 | 39% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 18% |
Agricultural and Biological Sciences | 8 | 16% |
Biochemistry, Genetics and Molecular Biology | 7 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Business, Management and Accounting | 1 | 2% |
Other | 4 | 8% |
Unknown | 19 | 39% |