Title |
Effects of food deprivation on the hypothalamic feeding-regulating peptides gene expressions in serotonin depleted rats
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Published in |
The Journal of Physiological Sciences, October 2013
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DOI | 10.1007/s12576-013-0296-1 |
Pubmed ID | |
Authors |
Mitsuhiro Yoshimura, Marina Hagimoto, Takanori Matsuura, Junichi Ohkubo, Motoko Ohno, Takashi Maruyama, Toru Ishikura, Hirofumi Hashimoto, Tetsuya Kakuma, Hironobu Yoshimatsu, Kiyoshi Terawaki, Yasuhito Uezono, Yumiko Toyohira, Nobuyuki Yanagihara, Yoichi Ueta |
Abstract |
We examined the effects of serotonin (5-HT) depletion induced by peripheral injection of 5-HT synthesis inhibitor p-chlorophenylalanine (PCPA) on the expression of feeding-regulating peptides expressions by using in situ hybridization histochemistry in adult male Wistar rats. PCPA pretreatment had no significant effect on basal levels of oxytocin, corticotropin-releasing hormone (CRH), thyrotropin-releasing hormone (TRH), pro-opiomelanocortin (POMC), cocaine and amphetamine-regulated transcript (CART), neuropeptide-Y (NPY), agouti-related protein (AgRP), melanin-concentrating hormone (MCH) or orexin in the hypothalamus. Food deprivation for 48 h caused a significant decrease in CRH, TRH, POMC, and CART, and a significant increase in NPY, AgRP and MCH. After PCPA treatment, POMC and CART did not decrease despite food deprivation. NPY was significantly increased by food deprivation with PCPA, but was attenuated compared to food deprivation without PCPA. These results suggest that the serotonergic system in the hypothalamus may be involved in the gene expression of POMC, CART, and NPY related to feeding behavior. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 24% |
Professor > Associate Professor | 4 | 16% |
Researcher | 4 | 16% |
Student > Doctoral Student | 3 | 12% |
Student > Master | 3 | 12% |
Other | 1 | 4% |
Unknown | 4 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 6 | 24% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 12% |
Neuroscience | 3 | 12% |
Nursing and Health Professions | 2 | 8% |
Medicine and Dentistry | 2 | 8% |
Other | 2 | 8% |
Unknown | 7 | 28% |