You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
| Title |
Nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation
|
|---|---|
| Published in |
BMC Chemistry, October 2017
|
| DOI | 10.1186/s13065-017-0338-5 |
| Pubmed ID | |
| Authors |
Min Peng, Liqiao Shi, Shaoyong Ke |
| Abstract |
A series of diamides derivatives containing nicotinamide unit were designed, synthesized and evaluated for their potential cytotoxic activities against human cancer cell lines. All the synthesized compounds were characterized using spectroscopic methods mainly including (1)H NMR, (13)C NMR and MS. The bio-evaluation results indicated that some of the obtained compounds (such as 4d, 4h, 4i) exhibited good to moderate cytotoxic effects on lung cancer cell lines (NCI-H460, A549, and NCI-H1975), especially, compound 4d exhibited the highly potential inhibitory activities against NCI-H460 cell line with the IC50 values of 4.07 ± 1.30 μg/mL, which might be developed as novel lead compounds for potential cytotoxic agents. |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 38% |
| Professor | 1 | 13% |
| Unspecified | 1 | 13% |
| Professor > Associate Professor | 1 | 13% |
| Student > Doctoral Student | 1 | 13% |
| Other | 0 | 0% |
| Unknown | 1 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 4 | 50% |
| Unspecified | 1 | 13% |
| Neuroscience | 1 | 13% |
| Unknown | 2 | 25% |