Title |
MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer
|
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Published in |
Molecular Cancer, October 2014
|
DOI | 10.1186/1476-4598-13-239 |
Pubmed ID | |
Authors |
Ayesha N Shajahan-Haq, Katherine L Cook, Jessica L Schwartz-Roberts, Ahreej E Eltayeb, Diane M Demas, Anni M Warri, Caroline O B Facey, Leena A Hilakivi-Clarke, Robert Clarke |
Abstract |
About 70% of all breast cancers are estrogen receptor alpha positive (ER+) and are treated with antiestrogens. However, 50% of ER + tumors develop resistance to these drugs (endocrine resistance). In endocrine resistant cells, an adaptive pathway called the unfolded protein response (UPR) is elevated that allows cells to tolerate stress more efficiently than in sensitive cells. While the precise mechanism remains unclear, the UPR can trigger both pro-survival and pro-death outcomes that depend on the nature and magnitude of the stress. In this study, we identified MYC, an oncoprotein that is upregulated in endocrine resistant breast cancer, as a regulator of the UPR in glucose-deprived conditions. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 1% |
Unknown | 80 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 24 | 30% |
Student > Master | 14 | 17% |
Researcher | 8 | 10% |
Student > Bachelor | 6 | 7% |
Student > Doctoral Student | 4 | 5% |
Other | 9 | 11% |
Unknown | 16 | 20% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 19 | 23% |
Medicine and Dentistry | 11 | 14% |
Mathematics | 1 | 1% |
Nursing and Health Professions | 1 | 1% |
Other | 5 | 6% |
Unknown | 17 | 21% |