Title |
Gene expression patterns and sequence polymorphisms associated with mosquito resistance to Bacillus thuringiensis israelensis toxins
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Published in |
BMC Genomics, October 2014
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DOI | 10.1186/1471-2164-15-926 |
Pubmed ID | |
Authors |
Laurence Després, Renaud Stalinski, Guillaume Tetreau, Margot Paris, Aurélie Bonin, Vincent Navratil, Stéphane Reynaud, Jean-Philippe David |
Abstract |
Despite the intensive use of Bacillus thuringiensis israelensis (Bti) toxins for mosquito control, little is known about the long term effect of exposure to this cocktail of toxins on target mosquito populations. In contrast to the many cases of resistance to Bacillus thuringiensis Cry toxins observed in other insects, there is no evidence so far for Bti resistance evolution in field mosquito populations. High fitness costs measured in a Bti selected mosquito laboratory strain suggest that evolving resistance to Bti is costly. The aim of the present study was to identify transcription level and polymorphism variations associated with resistance to Bti toxins in the dengue vector Aedes aegypti. We used RNA sequencing (RNA-seq) for comparing a laboratory-selected strain showing elevated resistance to Bti toxins and its parental non-selected susceptible strain. As the resistant strain displayed two marked larval development phenotypes (slow and normal), each phenotype was analyzed separately in order to evidence potential links between resistance mechanisms and mosquito life-history traits. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Portugal | 1 | 1% |
Germany | 1 | 1% |
France | 1 | 1% |
United Kingdom | 1 | 1% |
United States | 1 | 1% |
Unknown | 78 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 16 | 19% |
Student > Master | 11 | 13% |
Student > Bachelor | 11 | 13% |
Student > Doctoral Student | 9 | 11% |
Researcher | 9 | 11% |
Other | 12 | 14% |
Unknown | 15 | 18% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 37 | 45% |
Biochemistry, Genetics and Molecular Biology | 14 | 17% |
Medicine and Dentistry | 5 | 6% |
Environmental Science | 3 | 4% |
Immunology and Microbiology | 3 | 4% |
Other | 5 | 6% |
Unknown | 16 | 19% |