Title |
Pim-1 kinase is a target of miR-486-5p and eukaryotic translation initiation factor 4E, and plays a critical role in lung cancer
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Published in |
Molecular Cancer, October 2014
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DOI | 10.1186/1476-4598-13-240 |
Pubmed ID | |
Authors |
Wenshuai Pang, Xin Tian, Fan Bai, Ruiyu Han, Juan Wang, Haitao Shen, Xianghong Zhang, Yueping Liu, Xia Yan, Feng Jiang, Lingxiao Xing |
Abstract |
Pim-1 kinase is a proto-oncogene and its dysregulation contributes to tumorigenesis and progression of a variety of malignancies. Pim-1 was suggested as a therapeutic target of cancers. The functional relevance of Pim-1 and the mechanism underlying its dysregulation in lung tumorigenesis remained unclear. This study aimed to investigate if Pim-1 has important functions in non-small-cell lung cancer (NSCLC) by: 1) evaluating the clinicopathologic significance of Pim-1 through analysing its expression in 101 human NSCLCs tissues using quantitative PCR, Western Blot and immunohistochemical studies, 2) determining its role in NSCLC and drug resistance using in vitro assays, and 3) investigating the regulatory mechanism of Pim-1 dysregulation in lung tumorigenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 6 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Scientists | 1 | 17% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 52 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 31% |
Student > Bachelor | 8 | 15% |
Other | 7 | 13% |
Researcher | 5 | 10% |
Student > Postgraduate | 4 | 8% |
Other | 5 | 10% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 27% |
Medicine and Dentistry | 13 | 25% |
Biochemistry, Genetics and Molecular Biology | 9 | 17% |
Chemistry | 4 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 2 | 4% |
Unknown | 8 | 15% |