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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element
|
|---|---|
| Published in |
Genome Biology, October 2017
|
| DOI | 10.1186/s13059-017-1331-y |
| Pubmed ID | |
| Authors |
Oskar Marín-Béjar, Aina M. Mas, Jovanna González, Dannys Martinez, Alejandro Athie, Xabier Morales, Mikel Galduroz, Ivan Raimondi, Elena Grossi, Shuling Guo, Ana Rouzaut, Igor Ulitsky, Maite Huarte |
| Abstract |
It is now obvious that the majority of cellular transcripts do not code for proteins, and a significant subset of them are long non-coding RNAs (lncRNAs). Many lncRNAs show aberrant expression in cancer, and some of them have been linked to cell transformation. However, the underlying mechanisms remain poorly understood and it is unknown how the sequences of lncRNA dictate their function. Here we characterize the function of the p53-regulated human lncRNA LINC-PINT in cancer. We find that LINC-PINT is downregulated in multiple types of cancer and acts as a tumor suppressor lncRNA by reducing the invasive phenotype of cancer cells. A cross-species analysis identifies a highly conserved sequence element in LINC-PINT that is essential for its function. This sequence mediates a specific interaction with PRC2, necessary for the LINC-PINT-dependent repression of a pro-invasion signature of genes regulated by the transcription factor EGR1. Our findings support a conserved functional co-dependence between LINC-PINT and PRC2 and lead us to propose a new mechanism where the lncRNA regulates the availability of free PRC2 at the proximity of co-regulated genomic loci. |
X Demographics
The data shown below were collected from the profiles of 29 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 17% |
| United Kingdom | 2 | 7% |
| Canada | 2 | 7% |
| France | 1 | 3% |
| Ireland | 1 | 3% |
| Australia | 1 | 3% |
| India | 1 | 3% |
| Spain | 1 | 3% |
| Israel | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 14 | 48% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 62% |
| Scientists | 8 | 28% |
| Science communicators (journalists, bloggers, editors) | 2 | 7% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 112 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 26% |
| Researcher | 19 | 17% |
| Student > Master | 15 | 13% |
| Student > Bachelor | 11 | 10% |
| Student > Postgraduate | 4 | 4% |
| Other | 13 | 12% |
| Unknown | 21 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 60 | 54% |
| Agricultural and Biological Sciences | 15 | 13% |
| Engineering | 4 | 4% |
| Immunology and Microbiology | 4 | 4% |
| Medicine and Dentistry | 3 | 3% |
| Other | 3 | 3% |
| Unknown | 23 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2017.
All research outputs
#1,338,222
of 25,382,440 outputs
Outputs from Genome Biology
#1,045
of 4,468 outputs
Outputs of similar age
#27,319
of 339,185 outputs
Outputs of similar age from Genome Biology
#30
of 60 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,468 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 339,185 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.