Title |
Outer membrane protein P4 is not required for virulence in the human challenge model of Haemophilus ducreyi infection
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Published in |
BMC Microbiology, June 2014
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DOI | 10.1186/1471-2180-14-166 |
Pubmed ID | |
Authors |
Diane M Janowicz, Beth W Zwickl, Kate R Fortney, Barry P Katz, Margaret E Bauer |
Abstract |
Bacterial lipoproteins often play important roles in pathogenesis and can stimulate protective immune responses. Such lipoproteins are viable vaccine candidates. Haemophilus ducreyi, which causes the sexually transmitted disease chancroid, expresses a number of lipoproteins during human infection. One such lipoprotein, OmpP4, is homologous to the outer membrane lipoprotein e (P4) of H. influenzae. In H. influenzae, e (P4) stimulates production of bactericidal and protective antibodies and contributes to pathogenesis by facilitating acquisition of the essential nutrients heme and nicotinamide adenine dinucleotide (NAD). Here, we tested the hypothesis that, like its homolog, H. ducreyi OmpP4 contributes to virulence and stimulates production of bactericidal antibodies. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 3 | 30% |
Unspecified | 1 | 10% |
Lecturer | 1 | 10% |
Researcher | 1 | 10% |
Unknown | 4 | 40% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 2 | 20% |
Agricultural and Biological Sciences | 2 | 20% |
Unspecified | 1 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 10% |
Unknown | 4 | 40% |