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Outer membrane protein P4 is not required for virulence in the human challenge model of Haemophilus ducreyi infection

Overview of attention for article published in BMC Microbiology, June 2014
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Title
Outer membrane protein P4 is not required for virulence in the human challenge model of Haemophilus ducreyi infection
Published in
BMC Microbiology, June 2014
DOI 10.1186/1471-2180-14-166
Pubmed ID
Authors

Diane M Janowicz, Beth W Zwickl, Kate R Fortney, Barry P Katz, Margaret E Bauer

Abstract

Bacterial lipoproteins often play important roles in pathogenesis and can stimulate protective immune responses. Such lipoproteins are viable vaccine candidates. Haemophilus ducreyi, which causes the sexually transmitted disease chancroid, expresses a number of lipoproteins during human infection. One such lipoprotein, OmpP4, is homologous to the outer membrane lipoprotein e (P4) of H. influenzae. In H. influenzae, e (P4) stimulates production of bactericidal and protective antibodies and contributes to pathogenesis by facilitating acquisition of the essential nutrients heme and nicotinamide adenine dinucleotide (NAD). Here, we tested the hypothesis that, like its homolog, H. ducreyi OmpP4 contributes to virulence and stimulates production of bactericidal antibodies.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 30%
Unspecified 1 10%
Lecturer 1 10%
Researcher 1 10%
Unknown 4 40%
Readers by discipline Count As %
Medicine and Dentistry 2 20%
Agricultural and Biological Sciences 2 20%
Unspecified 1 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 10%
Unknown 4 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 October 2014.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from BMC Microbiology
#2,948
of 3,489 outputs
Outputs of similar age
#209,158
of 243,034 outputs
Outputs of similar age from BMC Microbiology
#53
of 67 outputs
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