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Distinct cerebrospinal fluid amyloid β peptide signatures in sporadic and PSEN1A431E-associated familial Alzheimer's disease

Overview of attention for article published in Molecular Neurodegeneration, January 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

blogs
1 blog

Citations

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75 Dimensions

Readers on

mendeley
90 Mendeley
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Title
Distinct cerebrospinal fluid amyloid β peptide signatures in sporadic and PSEN1A431E-associated familial Alzheimer's disease
Published in
Molecular Neurodegeneration, January 2010
DOI 10.1186/1750-1326-5-2
Pubmed ID
Authors

Erik Portelius, Ulf Andreasson, John M Ringman, Katharina Buerger, Jonny Daborg, Peder Buchhave, Oskar Hansson, Andreas Harmsen, Mikael K Gustavsson, Eric Hanse, Douglas Galasko, Harald Hampel, Kaj Blennow, Henrik Zetterberg

Abstract

Alzheimer's disease (AD) is associated with deposition of amyloid beta (Abeta) in the brain, which is reflected by low concentration of the Abeta1-42 peptide in the cerebrospinal fluid (CSF). There are at least 15 additional Abeta peptides in human CSF and their relative abundance pattern is thought to reflect the production and degradation of Abeta. Here, we test the hypothesis that AD is characterized by a specific CSF Abeta isoform pattern that is distinct when comparing sporadic AD (SAD) and familial AD (FAD) due to different mechanisms underlying brain amyloid pathology in the two disease groups.

Mendeley readers

The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
United Kingdom 1 1%
France 1 1%
Spain 1 1%
Belgium 1 1%
Unknown 84 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 24%
Student > Ph. D. Student 20 22%
Student > Bachelor 10 11%
Student > Doctoral Student 8 9%
Student > Master 8 9%
Other 12 13%
Unknown 10 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 30%
Neuroscience 13 14%
Medicine and Dentistry 10 11%
Biochemistry, Genetics and Molecular Biology 9 10%
Psychology 6 7%
Other 11 12%
Unknown 14 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2014.
All research outputs
#4,659,859
of 18,796,975 outputs
Outputs from Molecular Neurodegeneration
#431
of 729 outputs
Outputs of similar age
#56,290
of 242,230 outputs
Outputs of similar age from Molecular Neurodegeneration
#4
of 9 outputs
Altmetric has tracked 18,796,975 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 729 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,230 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.