Title |
The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis
|
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Published in |
Journal of Translational Medicine, October 2014
|
DOI | 10.1186/s12967-014-0293-z |
Pubmed ID | |
Authors |
Marco Genua, Sergio Rutella, Carmen Correale, Silvio Danese |
Abstract |
The Triggering Receptors Expressed on Myeloid cells (TREM) are a family of cell-surface molecules that control inflammation, bone homeostasis, neurological development and blood coagulation. TREM-1 and TREM-2, the best-characterized receptors so far, play divergent roles in several infectious diseases. In the intestine, TREM-1 is highly expressed by macrophages, contributing to inflammatory bowel disease (IBD) pathogenesis. Contrary to current understanding, TREM-2 also promotes inflammation in IBD by fueling dendritic cell functions. This review will focus specifically on recent insights into the role of TREM proteins in IBD development, and discuss opportunities for novel treatment approaches. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 2 | 2% |
Unknown | 97 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 21 | 21% |
Student > Master | 13 | 13% |
Student > Ph. D. Student | 12 | 12% |
Student > Bachelor | 9 | 9% |
Student > Postgraduate | 7 | 7% |
Other | 16 | 16% |
Unknown | 21 | 21% |
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Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
Other | 15 | 15% |
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