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D2-like receptor activation does not initiate a brain docosahexaenoic acid signal in unanesthetized rats

Overview of attention for article published in BMC Neuroscience, October 2014
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Title
D2-like receptor activation does not initiate a brain docosahexaenoic acid signal in unanesthetized rats
Published in
BMC Neuroscience, October 2014
DOI 10.1186/1471-2202-15-113
Pubmed ID
Authors

Ameer Y Taha, Lisa Chang, Mei Chen, Stanley I Rapoport, Epolia Ramadan

Abstract

The polyunsaturated fatty acid, docosahexaenoic acid (DHA), participates in neurotransmission involving activation of calcium-independent phospholipase A2 (iPLA2), which is coupled to muscarinic, cholinergic and serotonergic neuroreceptors. Drug induced activation of iPLA2 can be measured in vivo with quantitative autoradiography using 14C-DHA as a probe. The present study used this approach to address whether a DHA signal is produced following dompaminergic (D)2-like receptor activation with quinpirole in rat brain. Unanesthetized rats were infused intravenously with 14C-DHA one minute after saline or quinpirole infusion, and serial blood samples were collected over a 20-minute period to obtain plasma. The animals were euthanized with sodium pentobarbital and their brains excised, coronally dissected and subjected to quantitative autoradiography to derive the regional incorporation coefficient, k*, a marker of DHA signaling. Plasma labeled and unlabeled unesterified DHA concentrations were measured.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 5 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 1 20%
Student > Doctoral Student 1 20%
Student > Master 1 20%
Unknown 2 40%
Readers by discipline Count As %
Psychology 1 20%
Neuroscience 1 20%
Medicine and Dentistry 1 20%
Unknown 2 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 October 2014.
All research outputs
#20,241,019
of 22,768,097 outputs
Outputs from BMC Neuroscience
#1,053
of 1,243 outputs
Outputs of similar age
#217,265
of 260,456 outputs
Outputs of similar age from BMC Neuroscience
#16
of 19 outputs
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