Title |
Mining the tissue-tissue gene co-expression network for tumor microenvironment study and biomarker prediction
|
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Published in |
BMC Genomics, October 2013
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DOI | 10.1186/1471-2164-14-s5-s4 |
Pubmed ID | |
Authors |
Yang Xiang, Jie Zhang, Kun Huang |
Abstract |
Recent discovery in tumor development indicates that the tumor microenvironment (mostly stroma cells) plays an important role in cancer development. To understand how the tumor microenvironment (TME) interacts with the tumor, we explore the correlation of the gene expressions between tumor and stroma. The tumor and stroma gene expression data are modeled as a weighted bipartite network (tumor-stroma coexpression network) where the weight of an edge indicates the correlation between the expression profiles of the corresponding tumor gene and stroma gene. In order to efficiently mine this weighted bipartite network, we developed the Bipartite subnetwork Component Mining algorithm (BCM), and we show that the BCM algorithm can efficiently mine weighted bipartite networks for dense Bipartite sub-Networks (BiNets) with density guarantees. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Hungary | 1 | 2% |
Denmark | 1 | 2% |
Unknown | 40 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 21% |
Student > Ph. D. Student | 8 | 19% |
Student > Bachelor | 4 | 10% |
Student > Master | 4 | 10% |
Student > Doctoral Student | 3 | 7% |
Other | 8 | 19% |
Unknown | 6 | 14% |
Readers by discipline | Count | As % |
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Computer Science | 11 | 26% |
Agricultural and Biological Sciences | 8 | 19% |
Biochemistry, Genetics and Molecular Biology | 6 | 14% |
Medicine and Dentistry | 6 | 14% |
Engineering | 2 | 5% |
Other | 3 | 7% |
Unknown | 6 | 14% |