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Mining the tissue-tissue gene co-expression network for tumor microenvironment study and biomarker prediction

Overview of attention for article published in BMC Genomics, October 2013
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Title
Mining the tissue-tissue gene co-expression network for tumor microenvironment study and biomarker prediction
Published in
BMC Genomics, October 2013
DOI 10.1186/1471-2164-14-s5-s4
Pubmed ID
Authors

Yang Xiang, Jie Zhang, Kun Huang

Abstract

Recent discovery in tumor development indicates that the tumor microenvironment (mostly stroma cells) plays an important role in cancer development. To understand how the tumor microenvironment (TME) interacts with the tumor, we explore the correlation of the gene expressions between tumor and stroma. The tumor and stroma gene expression data are modeled as a weighted bipartite network (tumor-stroma coexpression network) where the weight of an edge indicates the correlation between the expression profiles of the corresponding tumor gene and stroma gene. In order to efficiently mine this weighted bipartite network, we developed the Bipartite subnetwork Component Mining algorithm (BCM), and we show that the BCM algorithm can efficiently mine weighted bipartite networks for dense Bipartite sub-Networks (BiNets) with density guarantees.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hungary 1 2%
Denmark 1 2%
Unknown 40 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 21%
Student > Ph. D. Student 8 19%
Student > Bachelor 4 10%
Student > Master 4 10%
Student > Doctoral Student 3 7%
Other 8 19%
Unknown 6 14%
Readers by discipline Count As %
Computer Science 11 26%
Agricultural and Biological Sciences 8 19%
Biochemistry, Genetics and Molecular Biology 6 14%
Medicine and Dentistry 6 14%
Engineering 2 5%
Other 3 7%
Unknown 6 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2014.
All research outputs
#20,655,488
of 25,373,627 outputs
Outputs from BMC Genomics
#8,709
of 11,244 outputs
Outputs of similar age
#168,837
of 223,620 outputs
Outputs of similar age from BMC Genomics
#147
of 211 outputs
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So far Altmetric has tracked 11,244 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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