Title |
Declining efficacy of artesunate plus sulphadoxine-pyrimethamine in northeastern India
|
---|---|
Published in |
Malaria Journal, July 2014
|
DOI | 10.1186/1475-2875-13-284 |
Pubmed ID | |
Authors |
Neelima Mishra, Kamlesh Kaitholia, Bina Srivastava, Naman K Shah, Jai Prakash Narayan, Vas Dev, Sobhan Phookan, Anupkumar R Anvikar, Roma Rana, Ram Suresh Bharti, Gagan Singh Sonal, Akshay Chand Dhariwal, Neena Valecha |
Abstract |
Anti-malarial drug resistance in Plasmodium falciparum in India has historically travelled from northeast India along the Myanmar border. The treatment policy for P. falciparum in the region was, therefore, changed from chloroquine to artesunate (AS) plus sulphadoxine-pyrimethamine (SP) in selected areas in 2005 and in 2008 it became the first-line treatment. Recognizing that resistance to the partner drug can limit the useful life of this combination therapy, routine in vivo and molecular monitoring of anti-malarial drug efficacy through sentinel sites was initiated in 2009. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 2% |
Burkina Faso | 1 | <1% |
Ghana | 1 | <1% |
Unknown | 97 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 22 | 22% |
Student > Master | 17 | 17% |
Student > Ph. D. Student | 16 | 16% |
Student > Bachelor | 7 | 7% |
Student > Doctoral Student | 6 | 6% |
Other | 17 | 17% |
Unknown | 16 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 28 | 28% |
Biochemistry, Genetics and Molecular Biology | 18 | 18% |
Agricultural and Biological Sciences | 13 | 13% |
Nursing and Health Professions | 3 | 3% |
Immunology and Microbiology | 3 | 3% |
Other | 17 | 17% |
Unknown | 19 | 19% |