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Rivaroxaban does not impair fracture healing in a rat femur fracture model: an experimental study

Overview of attention for article published in BMC Musculoskeletal Disorders, April 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

blogs
1 blog

Citations

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22 Dimensions

Readers on

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36 Mendeley
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Title
Rivaroxaban does not impair fracture healing in a rat femur fracture model: an experimental study
Published in
BMC Musculoskeletal Disorders, April 2015
DOI 10.1186/s12891-015-0502-9
Pubmed ID
Authors

Tim Klüter, Matthias Weuster, Stefan Brüggemann, Leif Menzdorf, Stefanie Fitschen- Oestern, Nadine Steubesand, Yahya Acil, Thomas Pufe, Deike Varoga, Andreas Seekamp, Sebastian Lippross

Abstract

The prescription of the oral anticoagulant rivaroxaban to prevent thromboembolic episodes associated with orthopaedic surgery has dramatically increased since it was introduced. Rivaroxaban is beeing prescribed although recent in-vitro studies revealed that it impaired osteoblast metabolism. In this study we analysed the effect of rivaroxaban on fracture healing in a rat femur fracture model. Femur fractures were created by a 3-point-bending device in 48 Wistar rats and subsequently stabilized by intramedullary nailing. After the surgical procedure animals were randomised into four groups. Two groups were fed with 3 mg rivaroxaban per kg body weight per day and two control groups were fed with chow only. Animals were euthanized 28 or 49 days after surgical procedure. Femurs underwent undecalcified histologic staining micro CT scanning and biomechanical testing. The statistical significance was evaluated using one-way Anova with Bonferroni correction. Micro CT-scans revealed significantly increased volume of bone tissue in the fracture zone between day 28 and 49. During the same time callus volume decreased significantly. Comparing the fracture zone of the rivaroxaban group to the control group the treated group revealed a larger callus and a marginal increase of the tissue mineral density. The torsional rigidity was not influenced by the treatment of rivaroxaban. In the present study we were able to demonstrate that rivaroxaban does not impair fracture healing in a rat femur fracture model. Considering the fact that low molecular weight heparins delay fracture healing significantly, rivaroxaban might be an improved alternative.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Turkey 1 3%
Slovenia 1 3%
Unknown 33 92%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 19%
Researcher 7 19%
Student > Postgraduate 3 8%
Student > Doctoral Student 3 8%
Student > Ph. D. Student 3 8%
Other 9 25%
Unknown 4 11%
Readers by discipline Count As %
Medicine and Dentistry 23 64%
Agricultural and Biological Sciences 3 8%
Nursing and Health Professions 1 3%
Engineering 1 3%
Unknown 8 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 May 2015.
All research outputs
#1,732,854
of 8,605,600 outputs
Outputs from BMC Musculoskeletal Disorders
#489
of 2,141 outputs
Outputs of similar age
#26,992
of 113,595 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#15
of 69 outputs
Altmetric has tracked 8,605,600 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,141 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 113,595 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.