Title |
Asthma-COPD overlap is not a homogeneous disorder: further supporting data
|
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Published in |
Respiratory Research, November 2017
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DOI | 10.1186/s12931-017-0667-x |
Pubmed ID | |
Authors |
Luis Pérez-de-Llano, Borja G. Cosio, on behalf of the CHACOS study group |
Abstract |
Asthma-COPD ovelap (ACO) is an umbrella term that encompasses patients with COPD and eosinophilic inflammation (e-COPD) and smoking asthmatics with non-fully reversible airflow obstruction (SA). We compared the clinical characteristics and the inflammatory profile of e-COPD and SA. Patients classified as e-COPD were older and more often male and showed significantly impaired pulmonary function (likely explained by a heavier smoking habit). On the contrary, SA had more atopic features, more reversibility of airflow obstruction and higher IgE levels. The concentrations of IL-5, IL-13, IL-8, IL-6, TNF-α, IL17 in serum were similar between the 2 groups. However, Th2-related biomarkers (periostin, FeNO and blood eosinophils) shower higher median values in e-COPD patients. Our findings reinforce the notion that ACO is a heterogeneous disorder and, as a consequence, it might be unacceptable to offer the same treatment for two related but different conditions. |
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Geographical breakdown
Country | Count | As % |
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Spain | 8 | 36% |
United Kingdom | 4 | 18% |
Moldova, Republic of | 1 | 5% |
Colombia | 1 | 5% |
Grenada | 1 | 5% |
Argentina | 1 | 5% |
Unknown | 6 | 27% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 18 | 82% |
Practitioners (doctors, other healthcare professionals) | 3 | 14% |
Scientists | 1 | 5% |
Mendeley readers
Geographical breakdown
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Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 13% |
Professor | 6 | 11% |
Student > Master | 6 | 11% |
Other | 5 | 9% |
Librarian | 3 | 6% |
Other | 6 | 11% |
Unknown | 20 | 38% |
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Medicine and Dentistry | 22 | 42% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Computer Science | 2 | 4% |
Nursing and Health Professions | 1 | 2% |
Other | 2 | 4% |
Unknown | 22 | 42% |