Title |
Familial mixed nephrocalcinosis as a cause of chronic kidney failure: two case reports
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Published in |
Journal of Medical Case Reports, October 2014
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DOI | 10.1186/1752-1947-8-355 |
Pubmed ID | |
Authors |
Pedro Francisco Ferraz de Arruda, Márcio Gatti, José Germano Ferraz de Arruda, Fernando Nestor Fácio, Luis Cesar Fava Spessoto, Laísa Ferraz de Arruda, José Maria Pereira de Godoy, Moacir Fernandes Godoy |
Abstract |
Nephrocalcinosis consists of the deposition of calcium salts in the renal parenchyma and is considered the mixed form when it involves the renal cortex and medulla. The main etiological agents of this condition are primary hyperparathyroidism, renal tubular acidosis, medullary sponge kidney, hyperoxaluria and taking certain drugs. These factors can lead to hypercalcemia and/or hypercalciuria, which can give rise to nephrocalcinosis.Case presentations: Patient 1 was a 48-year-old Caucasian woman with a history of bilateral nephrocalcinosis causing chronic kidney failure. Imaging examinations (X-ray, ultrasound and computed tomography of the abdomen) revealed extensive calcium deposits in the renal parenchyma, indicating nephrocalcinosis as the causal factor of the disease. Patient 2 is the 45-year-old brother of patient 1. He exhibited an advanced stage of chronic kidney failure. As nephrocalcinosis is considered to have a genetic component, a family investigation revealed this condition in patient 2. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 2 | 14% |
Student > Ph. D. Student | 2 | 14% |
Student > Postgraduate | 2 | 14% |
Other | 1 | 7% |
Student > Master | 1 | 7% |
Other | 3 | 21% |
Unknown | 3 | 21% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 5 | 36% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Agricultural and Biological Sciences | 1 | 7% |
Nursing and Health Professions | 1 | 7% |
Other | 2 | 14% |
Unknown | 3 | 21% |