Title |
Comparative transcriptomics reveals striking similarities between the bovine and feline isolates of Tritrichomonas foetus: consequences for in silico drug-target identification
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Published in |
BMC Genomics, November 2014
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DOI | 10.1186/1471-2164-15-955 |
Pubmed ID | |
Authors |
Victoria Morin-Adeline, Rodrigo Lomas, Denis O’Meally, Colin Stack, Ana Conesa, Jan Šlapeta |
Abstract |
Few, if any, protozoan parasites are reported to exhibit extreme organ tropism like the flagellate Tritrichomonas foetus. In cattle, T. foetus infects the reproductive system causing abortion, whereas the infection in cats results in chronic large bowel diarrhoea. In the absence of a T. foetus genome, we utilized a de novo approach to assemble the transcriptome of the bovine and feline genotype to identify host-specific adaptations and virulence factors specific to each genotype. Furthermore, a subset of orthologs was used to characterize putative druggable targets and expose complications of in silico drug target mining in species with indefinite host-ranges. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
France | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 27% |
Student > Master | 7 | 16% |
Researcher | 6 | 13% |
Student > Bachelor | 5 | 11% |
Student > Doctoral Student | 5 | 11% |
Other | 5 | 11% |
Unknown | 5 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 14 | 31% |
Agricultural and Biological Sciences | 12 | 27% |
Veterinary Science and Veterinary Medicine | 8 | 18% |
Computer Science | 2 | 4% |
Materials Science | 1 | 2% |
Other | 0 | 0% |
Unknown | 8 | 18% |