Title |
A nucleosomal approach to inferring causal relationships of histone modifications
|
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Published in |
BMC Genomics, January 2014
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DOI | 10.1186/1471-2164-15-s1-s7 |
Pubmed ID | |
Authors |
Ngoc Tu Le, Tu Bao Ho, Bich Hai Ho, Dang Hung Tran |
Abstract |
Histone proteins are subject to various posttranslational modifications (PTMs). Elucidating their functional relationships is crucial toward understanding many biological processes. Bayesian network (BN)-based approaches have shown the advantage of revealing causal relationships, rather than simple cooccurrences, of PTMs. Previous works employing BNs to infer causal relationships of PTMs require that all confounders should be included. This assumption, however, is unavoidably violated given the fact that several modifications are often regulated by a common but unobserved factor. An existing non-parametric method can be applied to tackle the problem but the complexity and inflexibility make it impractical. |
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Unknown | 1 | 7% |
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