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DiffVar: a new method for detecting differential variability with application to methylation in cancer and aging

Overview of attention for article published in Genome Biology, September 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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15 X users

Citations

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91 Dimensions

Readers on

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134 Mendeley
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2 CiteULike
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Title
DiffVar: a new method for detecting differential variability with application to methylation in cancer and aging
Published in
Genome Biology, September 2014
DOI 10.1186/s13059-014-0465-4
Pubmed ID
Authors

Belinda Phipson, Alicia Oshlack

Abstract

Methylation of DNA is known to be essential to development and dramatically altered in cancers. The Illumina HumanMethylation450 BeadChip has been used extensively as a cost-effective way to profile nearly half a million CpG sites across the human genome. Here we present DiffVar, a novel method to test for differential variability between sample groups. DiffVar employs an empirical Bayes model framework that can take into account any experimental design and is robust to outliers. We applied DiffVar to several datasets from The Cancer Genome Atlas, as well as an aging dataset. DiffVar is available in the missMethyl Bioconductor R package.

X Demographics

X Demographics

The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Sweden 3 2%
United States 1 <1%
Turkey 1 <1%
Belgium 1 <1%
Unknown 128 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 44 33%
Researcher 42 31%
Student > Bachelor 9 7%
Student > Postgraduate 6 4%
Student > Master 5 4%
Other 15 11%
Unknown 13 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 41 31%
Biochemistry, Genetics and Molecular Biology 40 30%
Medicine and Dentistry 10 7%
Computer Science 9 7%
Mathematics 3 2%
Other 11 8%
Unknown 20 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 October 2019.
All research outputs
#4,759,600
of 25,373,627 outputs
Outputs from Genome Biology
#2,774
of 4,467 outputs
Outputs of similar age
#48,487
of 263,029 outputs
Outputs of similar age from Genome Biology
#53
of 103 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,029 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 103 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.