Title |
Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner
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Published in |
Stem Cell Research & Therapy, November 2014
|
DOI | 10.1186/scrt512 |
Pubmed ID | |
Authors |
Alexander Birbrair, Tan Zhang, Daniel Clark Files, Sandeep Mannava, Thomas Smith, Zhong-Min Wang, Maria Laura Messi, Akiva Mintz, Osvaldo Delbono |
Abstract |
Fibrosis, or scar formation, is a pathological condition characterized by excessive production and accumulation of collagen, loss of tissue architecture, and organ failure in response to uncontrolled wound healing. Several cellular populations have been implicated, including bone marrow-derived circulating fibrocytes, endothelial cells, resident fibroblasts, epithelial cells, and recently, perivascular cells called pericytes. We previously demonstrated pericyte functional heterogeneity in skeletal muscle. Whether pericyte subtypes are present in other tissues and whether a specific pericyte subset contributes to organ fibrosis are unknown. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | <1% |
United States | 1 | <1% |
India | 1 | <1% |
Italy | 1 | <1% |
Unknown | 250 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 49 | 19% |
Student > Master | 49 | 19% |
Researcher | 30 | 12% |
Student > Bachelor | 27 | 11% |
Student > Doctoral Student | 16 | 6% |
Other | 37 | 15% |
Unknown | 46 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 51 | 20% |
Biochemistry, Genetics and Molecular Biology | 44 | 17% |
Medicine and Dentistry | 38 | 15% |
Neuroscience | 19 | 7% |
Engineering | 11 | 4% |
Other | 34 | 13% |
Unknown | 57 | 22% |